I live in peace with the nettles in my garden… until one of them stings me. Then I obliterate the entire species (as far as I am capable). Why have the nettles not evolved a better (i.e. stingless) strategy? There are no large herbivores in my garden, so they are under no pressure to remain "armed".
The same can be said for thistles, brambles and all sorts of other, painful encounters.