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Question about lipolysis

Restricting carbs on the Atkins diet induces ketosis/lipolysis, and within just a couple of days of diligent dieting, you'll find lipolysis testing strips start to turn purple.  How can one tell that these ketone bodies being excreted in the urine are from burning body fat as opposed to the dietary fat consumed? (The diet books don't address this).

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  • Asked by Wonderer
  • on 2010-10-03 23:32:48
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Categories: Human Body.

Tags: Dieting.

 

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Jon-Richfield says:

You can't. Fundamentally there is precious little difference between the metabolism of stored and mobilised fatty acids, and that of just-assimilated fatty acids from the gut. In fact, if the fatty acids in the diet are equivalent to the fatty acids mobilised from your cells, then there is no effective difference. The question of which molecule gets metabolised first, is essentially a matter of statistics.

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posted on 2010-10-05 13:37:52 | Report abuse

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Wonderer says:

Thanks for clarifying this!  So, strictly speaking, the purple colour is merely a sign that you're no longer metabolising glucose or glycogen ( something you already know if you've sworn off bread etc!!).   The colour purple doesn't mean that your body has necessarily turned its attention to the thunder in the thighs when there's also perfectly good fat in the new diet.  No wonder the diet books keep mum on this point!  Thanks for answering & so promptly too.

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posted on 2010-10-05 23:41:26 | Report abuse

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Jon-Richfield says:

You are welcome to that answer as far as it goes, but do bear in mind that your metabolism is a complex, complex system, and that the reply that I gave was merely a simplification of one aspect.

Actually, metabolism of your lipids, whether dietary or mobilised, involves a great deal of converting of fatty acids to and from acetate. Any fatty acid that your enzymes can handle can end up as acetate, and by far the most of the fatty acid that you build up again from acetate for storage and the like, ends up as the same saturated fatty acids, largely stearate.

In other words, if you do not eat large quantities of fats or fatty acids, your bodily fat fairly soon converges on a standard constitution. Now, if you stop eating fat, making up for it with carbohydrates, or worse, amino acids, then the end product before final oxidation also is acetate (not counting various waste products, in particular those from the metabolism of amino acids). When that acetate winds up in either your blood or in adipose cells, it largely is metabolised into fat, and in particular into a constitution of fat typical of your body. That is why energy-rich foods are largely interchangeable in terms of the kind of fat they produce.

The body however does not necessarily process all types of foods equally efficiently or healthily, especially if there is a sudden demand on the body to adjust its metabolism to a new, unbalanced diet. That is why the Atkins diet at first seems very effective; your body simply is not coping very well with all that perfectly good, but expensive and poorly balanced meat and similar foods. Once it does adjust, the rate of weight loss often decreases, and of course the rate of production of unhealthy metabolites increases. For such reasons, the Atkins diet tends to win a lot of converts in the first week or two, but very few that stay the course. It makes them feel lousy, it costs a lot of money, and it is diminishingly effective.

Sorry to sound so tiresomely virtuous about it, but a healthily balanced diet in appropriate quantities without snacks or excuses, together with healthy exercise, not only is the only healthy way to adjust your weight and keep it adjusted, but in the longer run it is the easiest. What is more, if you wind it up properly so that at the end of your diet you are easing into a healthily balanced, comfortable eating pattern, it is very easy to continue with that style of living without either backsliding or discomfort.

Enjoy!

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posted on 2010-10-06 15:23:27 | Report abuse

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petethebloke says:

Just right Jon. Also bear in mind that exercise is good for you BUT the amount westerners manage is rarely enough for weight loss on its own. After all, a Mars bar gives you enough energy to walk about 3 miles.

Most of the people I've known who are anxious about their weight have reached near obsession levels. Much healthier to enjoy your food, stop eating if you're no longer hungry and exercise sensibly.

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posted on 2010-10-06 15:43:55 | Report abuse


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