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How complicated does a molecule have to be before it can be said to have the attributes of life?

Lois Pasteur demonstrated that life comes from life. That is rotten meat doesn't spontaneously produce flies. And Darwin postulates that all life evolved from earlier forms of life. The paradox here is, as I see it, that when we extrapolate back to the creation of the planet we're told that it was a sterile hot and hostile place. The leading theory seems to be that the hotch potch of chemicals in the primitive earth somehow came together to form life. My query is just how "simple" does a molecule have to be to be on the border between life and non life?

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  • Asked by qestor
  • on 2010-11-25 09:12:08
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Tags: Astronomy, evoltion, molecularbiology.

 

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Jon-Richfield says:

I would say that complexity of the molecule is not any simple function of its livingness. No matter how small a structure you could produce that everyone would agree to be in some way a reasonable example of a living organism, I could produce you a much larger one that everyone would agree to be non-living.

Then again, consider some virus or viroid  molecules; would you call them living? One could make a good case for it,  but only if you supply them with a living organism as a host.

Your question raises some challenging points that you need to address more clearly before we could give you a definite reply, if at all.

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posted on 2010-11-25 20:00:59 | Report abuse

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qestor says:

Thank you jon. I may have phrased the question badly as you missed the trap in it. My question is where do we draw the line between life and non life? Indeed does the question make any sense. If we assume that more primitive life forms get simpler and simpler until we reach the so called building blocks of life, i.e. organic chemicals, do we attach the definition of life to them? And since organic chemicals can be made from inorganic ones do we have to assume that everything has a life force? This may sound like a reducto ad absurdum argument but I am being serious. Maybe by framing my question in terms of a molecule I was being niave; it could be that life comes from a cocktail of chemicals. For instance, I'm alive (at the time of writing) but any particular part of me could be considered as very fresh meat; and I believe that my hair is technically dead.

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posted on 2010-11-25 22:17:28 | Report abuse


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Georg says:

 How complicated does a molecule have to be before it can be said to have the attributes of life?

 

What measure would  You apply for this "complicatedness"?

And the second problem: there is no example for a living

single molecule, all known living units consist of thousands, 

maybe millions of molecules (even when things like water

molecules are not counted)

Georg

 

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posted on 2010-11-25 22:04:08 | Report abuse

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qestor says:

Thank you Georg. The very point you  make has occured to me as you may read in my reply to jon. Being no biologist, but versed in chemistry, the link between the two intrigues and iterests me.

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posted on 2010-11-25 22:23:40 | Report abuse


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MikeAdams#367 says:

In order to provide an answer we need to know how you will distinguish when to recognize something is living. Unless there are precise criteria then we will end up debating whether or not something is living, rather than the point you are asking.

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posted on 2010-11-26 01:13:44 | Report abuse

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qestor says:

My point exactly.

Perhaps the simplist criteria could be that the molecule or system (I think I'll stick to system) must be capable of self replication.

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posted on 2010-11-26 08:37:12 | Report abuse


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Jon-Richfield says:

 

I would say that complexity of the molecule is not any simple function of its livingness. No matter how small a structure you could produce that everyone would agree to be in some way a reasonable example of a living organism, I could produce you a much larger one that everyone would agree to be non-living.

Then again, consider some virus or viroid  molecules; would you call them living? One could make a good case for it,  but only if you supply them with a living organism as a host.

Your question raises some challenging points that you need to address more clearly before we could give you a definite reply, if at all.

 

You said: “Indeed does the question make any sense.”

Sorta-kinda... yes. However, it is a very begging question because it conflates or confuses (or both) several aspects. The problem is to tease them out and deal with them in proper, meaningful contexts. And if you think that we have the resources to do so properly, I commend your optimism. Still if we avoided all questions that we were as yet unable to formulate cogently, we would make miserably poor progress. So let’s see whether we can make any sense of it at all. At the heart of the question is possibly one (maybe more) of the most challenging and as yet barely engaged open questions in science (or possibly proto-science?) Namely: what is life as opposed to complexity and organisation and possibly in parallel or even as the same matter, what is mind as opposed to computational power? I cannot answer either, or to what extent they resemble, but...

You said: “My question is where do we draw the line between life and non life?”

 

I say: I am not sure that it is a matter of drawing a line. I am not at all sure that it is a matter of drawing a fuzzy, twilit border region. I suspect that we are looking in the wrong dimension rather than wrong direction. See the attached pictures by Escher for two analogies out of many.

 

You said: “If we assume that more primitive life forms get simpler and simpler until we reach the so called building blocks of life, i.e. organic chemicals...”

 

I say: That is a biiig assumption! You could make a reduced version of me by leaving off suitably selected molecules, but only up to a point. Pretty soon you will get to the point where the reducee is undebatably (and by some people unlamentably) not Jon, whether it is functionally alive or not. You don’t get a smaller copy of me by splitting me down the middle for example, an assertion that I firmly refuse to support by demonstration, any more than by splitting your car down the midline would give you two cars, no matter how well it might work with planarians. And yet, there are undeniably independently living and viable creatures far smaller than the split car, the split Jon, or the split planarian. A big assumption indeed in more dimensions than one. It is not only whether you could do it, but why?  Why should any of the building blocks of a living thing be living, any more than the building blocks of my house are a house, or the methyne groups of a benzene ring be miniature benzenes?

 

Fallacy of composition?

 

Not to put it too kindly, that is not so much a reductio ad absurdum as a reductio ab absurdum... No?

 

But again, it becomes possible in principle to reduce existing simple forms of life, such as large prokaryotes into smaller prokaryotes, possibly with more constrained functions, beginning with cells far smaller than any cell of yours or mine, and making them smaller still. And yet we are still nowhere near Georg’s observation that we know of no living molecule, even if that would be where any such process would (too late for life) end.

 

Next we encounter another dimension. You are living; so am I. So is my cat and my neighbouring mice and a rather intriguing earwig I missed photographing up a mountain yesterday, and a rotiferan in our neighbouring dam.

 

Yes?

 

Are you sure?

 

Without the wherewithal to support life? I don’t think so, not for long.

 

If at all.

 

So what is all this about living things and non-living things? Life obviously seems to require a system in which to work, or it is hard to justify calling it life. You deny the validity of calling an amoeba non-living if it has no droplet of water to live in and bacteria to feed on? How about Legionella, that is a true bacterium, though it needs a eukaryotic cell to survive in? Is it alive in the absence of a cell? Or what about a mitochondrian, most of whose needs are supported in its enveloping cell? Then who are you to forbid calling a viroid living, though it needs the cells of say, a potato or a human for its reproduction? Even though it is a single molecule, no proteins, just a ring of RNA?

 

But is the system the living thing? I saw a tiny, immature toad grasshopper the same morning as I saw that earwig. It looked pretty lively (though it did permit me a few photos!) Am I to deny that it was alive any more than any of the mitochondria in one of its muscle cells in isolation, or one of its protein molecules, because it was sitting on a rock and not actually including any of the grass it might normally eat?

 

If so you may be right, but it LOOKED pretty lively, and I think some people might beg to differ.

 

As Leonard  Cohen said:

“A person who eats meat

wants to get his teeth into something

A person who does not eat meat

wants to get his teeth into something else

If these thoughts interest you for even a moment

you are lost"

 

 

You ask: “And since organic chemicals can be made from inorganic ones do we have to assume that everything has a life force? This may sound like a reducto ad absurdum argument but I am being serious.”

 

RAA arguments are supposed to be serious where I come from. If we could assume a life force abstracted from life, that would solve a lot of problems, but I am not sure it wouldn’t create more than it would solve. What life would a life force force when it wasn’t forcing life? It would have a long, lonely time of it in the eight or ten billion years before the right molecules began to fit together on a certain cloudy planet some 3 to the 17 seconds ago!

 

You say: “Maybe by framing my question in terms of a molecule I was being niave...”

 

Maybe.

“...it could be that life comes from a cocktail of chemicals.”

 

No maybe about THAT being naïve! Cocktail indeed! And a cocktail of bricks would be a house? Maybe?

 

You said to Georg: “...the link between the two intrigues and interests me...”

 

Now, there we are at one!

Georg says: “...there is no example for a living single molecule, all known living units consist of thousands, maybe millions of molecules...”

 

This is true Georg, and I do not expect us ever to find a counter-example on this planet or elsewhere, in spite of my example of viroids. However, we know of no theoretical reason why no such molecule could exist, at lest as alive as say, an Amoeba.

 

As you and

Mike agreed pretty well about: “In order to provide an answer we need to know how you will distinguish when to recognize something is living. Unless there are precise criteria then we will end up debating whether or not something is living, rather than the point you are asking.”

 

So do the rest of us, I bet.

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posted on 2010-11-26 19:32:22 | Report abuse

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Georg says:

However, we know of no theoretical reason why no such molecule could exist, at lest as alive as say, an Amoeba.

 

Hello Jon,

I know of one one border:

When molecular weigt of macromolecules exeeds some

border (exact value depends on nature of bonds involved

and time of stability demanded and kind of chemical attack)

the molecule becomes sure to be broken at some point

wthin the "lifetime".

So, the hypothetical supermolecule able to self-replication

has to include some self-repair system which works even

when a bond within the self-repair department is broken.

That seems to be a cat chasing its own tail.

Georg

 

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posted on 2010-11-27 11:22:00 | Report abuse

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Jon-Richfield says:

Hi Georg,

Your constraint as stated is perfectly valid in practical terms, and I would not for a moment argue that a unimolecular organism of complexity rivalling say, our textbook example, Amoeba, would be viable. In fact I say so for more reasons than the one you mention. (Mind you, it might be fun to design a science fiction example...)

However, I mentioned it as an abstract Gedankenexperiment, not an evolutionarily viable prospect. One reason that I do not believe that it would be viable is that every other viable organism much beyond viroids has some sort of modular structure, where each of the modules has its own (not necessarily individual) evolutionary history. To achieve such flexibility in a single molecular structure would be challenging, would lack any functional advantage that I can think of, and for it to arise by the normal, non-teleological mechanisms of biological evolution seems to me beyond reasonable expectation.

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posted on 2010-11-27 17:49:54 | Report abuse


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petrushka.googol says:

Unicellular organisms like the amoeba are considered to be the most primitive of life forms as they contain protoplasm which is the physical basis of life.

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posted on 2010-11-27 16:42:44 | Report abuse

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Jon-Richfield says:

Thanks for the comment PG, but I am afraid it is drastically out of date (about a century or half a century, depending on your criteria). The very concept of protoplasm no longer has much application in biology, and certainly none as a term for a substance rather than a structure. The amoeba nowadays is regarded as a very advanced organism, a eukaryote, far from the limits of simplicity of living organisms as we are discussing the concepts here.

I don't know how much interest you take in such matters, but if you do, you might find it useful to check a few entries in Wikipedia, including Protoplasm, Eukaryote, three-domain system, and whatever links those lead you to. If you encounter any specific difficulties en route, please feel welcome to ask here. Everyone must start somewhere!  :-)

Cheers,

Jon     

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posted on 2010-11-27 17:36:46 | Report abuse


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