How does one answer a question like that meaningfully? What counts as human? Suppose that all the humans in every generation who could beat 10 secs/100M were to cooperatively mate at each generation and select the top million offspring for the next generation of the experiment for 100 generations. That would be a very modest experiment, evolutionarily speaking; 2000 years or less. I leave it to you to imagine the result after 100000 generations. I do not even dream of asking you to imagine the outcome of 1000 years of genetic engineering.
Now, would you call the offspring that resulted human? If not, why not? Because they could sprint faster than their grandparents? Our sprinters already do that. Because they don't look human? Who are we to call people with small feet (or hooves), large, forward-directed nostrils, flat ears, smooth heads, and massive thighs inhuman?
Well, I would guess something like 6 to 8 seconds.
And you?