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why is uracil is replaced by thymine in RNA?

While other bases can undergo deamination (or other chemical changes) they do not give rise to another standard base and can immediately be seen as a mistake. For example adenine gets converted to hypoxanthine.

 

So, in a C-->U change in RNA there is no way to tell that anything happened, since both are naturally occurring bases in RNA. Any other change (A-->HX) is spotted as an abnormal base.

By contrast, in DNA, by using thymine instead of uracil, the C-->U is seen as a mistake as uracil should never be there 

 

I don’t know if this clarifies my point, or makes it even murkier

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Jon-Richfield says:

Well, that is as reasonable an answer as one could ask for. You definitely addressed a large part of the basis for my doubts.  I hadn't bothered to check the consequences of deamination for other bases. I'm still sceptical, but it definitely is a good bit of thinking!

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posted on 2011-03-08 18:18:03 | Report abuse


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