It's generally said that QWERTY keyboards were originally designed to be inefficient, to slow down some keystrokes to prevent jamming of typebars in mechanical typewriters. On the other hand, there are some free market think tanks that claim the QWERTY keyboard really is the most efficient, though their claims may be biased.
Being old enough to have used an old "typebar" typewriter, the most common jams I seem to remember were associated with typing numbers such as "12" (which might be consistent with Benford's Law). If an empirical approach was used to prevent jams, one might have expected the numbers across the top of the keyboard (or separate calculator-like keypads, if such machines used similar mechanisms) to have been scrambled as well (though old typewriters did seem to use something like the letter "I" for the number one).
Since one commonly hears people bringing up QWERTY keyboards as an example of "entrenched inefficiencies," has newer technology (and the advent of "thumb typing" and the like) caused new keyboard formats to flourish?